RT Journal Article
SR Electronic
T1 Synaptic Communication
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw162
OP tw162
DO 10.1126/stke.3852007tw162
VO 2007
IS 385
A1 Stern, Peter
YR 2007
UL http://stke.sciencemag.org/content/2007/385/tw162.abstract
AB The traditional view of pyramidal neurons, which are excitatory, is that they can only excite their downstream target cells. However, Ren et al. report that cortical pyramidal neurons can elicit an inhibitory synaptic current in another neighboring pyramidal neuron. These unusual responses were caused by axo-axonic disynaptic connections onto γ-aminobutyric acid (GABA)-releasing terminals located on or near the soma of the postsynaptic pyramidal cell. These so-called interpyramidal inhibitory postsynaptic currents were remarkably large and frequent, which suggests that they play an important role. M. Ren, Y. Yoshimura, N. Takada, S. Horibe, Y. Komatsu, Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons. Science 316, 758-761 (2007). [Abstract] [Full Text]