PT  - JOURNAL ARTICLE
AU  - Simpson, Stephen
TI  - IP<sub>4</sub> Recruits Signaling Proteins
AID  - 10.1126/stke.3862007tw169
DP  - 2007 May 15
TA  - Science's STKE
PG  - tw169--tw169
VI  - 2007
IP  - 386
4099  - http://stke.sciencemag.org/content/2007/386/tw169.short
4100  - http://stke.sciencemag.org/content/2007/386/tw169.full
SO  - Sci. STKE2007 May 15; 2007
AB  - Inositol phosphates are important intracellular second messengers in eukaryotic cells. In particular, higher-order inositol polyphosphates regulate a range of biological processes, from chromatin remodeling to calcium signaling. Huang et al. (see the Perspective by Irvine) now report that inositol (1,3,4,5)-tetrakisphosphate (IP4) plays an unexpected role in T cells by modifying a well-established protein recruitment pathway. Soluble IP4 in the cell was found to lock onto plekstrin homology domains that regulate the recruitment of signaling proteins to the cell membrane for activation during T cell development. Y. H. Huang, J. A. Grasis, A. T. Miller, R. Xu, S. Soonthornvacharin, A. H. Andreotti, C. D. Tsoukas, M. P. Cooke, K. Sauer, Positive regulation of Itk PH domain function by soluble IP4. Science 316, 886-889 (2007). [Abstract] [Full Text] R. Irvine, The art of the soluble. Science 316, 845-846 (2007). [Summary] [Full Text]