RT Journal Article
SR Electronic
T1 Changing the Histone Landscape
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw90
OP tw90
DO 10.1126/stke.3772007tw90
VO 2007
IS 377
A1 Riddihough, Guy
YR 2007
UL http://stke.sciencemag.org/content/2007/377/tw90.abstract
AB In eukaryotes, histone proteins help package DNA into chromatin. Marks or covalent modifications on histones play an important role in the epigenetic regulation of gene expression, as well as DNA replication and repair. It has been assumed that the histones within chromatin will be fairly stable. Mito et al. and Dion et al. instead show that for certain regions of the genome in yeast and in Drosophila, there is a dramatic variation in histone H3 turnover rates. Coding regions in the genome were unexpectedly "quiet," and protein binding sites in promoters--and especially boundary elements--showed a very high level of turnover. In regions of high turnover, epigenetic marks must be in a state of constant flux, which provides the potential for their rapid and dynamic regulation. Y. Mito, J. G. Henikoff, S. Henikoff, Histone replacement marks the boundaries of cis-regulatory domains. Science 315, 1408-1411 (2007). [Abstract] [Full Text] M. F. Dion, T. Kaplan, M. Kim, S. Buratowski, N. Friedman, O. J. Rando, Dynamics of replication-independent histone turnover in budding yeast. Science 315, 1405-1408 (2007). [Abstract] [Full Text]