PT  - JOURNAL ARTICLE
AU  - Gerrow, Kimberly
AU  - El-Husseini, Alaa
TI  - Receptors Look Outward: Revealing Signals That Bring Excitation to Synapses
AID  - 10.1126/stke.4082007pe56
DP  - 2007 Oct 16
TA  - Science's STKE
PG  - pe56--pe56
VI  - 2007
IP  - 408
4099  - http://stke.sciencemag.org/content/2007/408/pe56.short
4100  - http://stke.sciencemag.org/content/2007/408/pe56.full
SO  - Sci. STKE2007 Oct 16; 2007
AB  - Defining the molecular mechanisms that govern the trafficking of glutamate receptors to excitatory synaptic contacts is fundamental to understanding the mechanisms that regulate synapse maturation and neuronal excitability. Previous studies have identified several scaffolding molecules and adaptor proteins that regulate glutamate receptor trafficking and retention at the synapse. Recent work, however, has elucidated new players such as the N-cadherin adhesion complex, and members of the pentraxin family that regulate clustering of glutamate receptors through extracellular protein interactions. Here, we highlight recently identified modes that regulate glutamate receptor clustering, and discuss their relevance to synapse maturation.