PT  - JOURNAL ARTICLE
AU  - Ray, L. Bryan
TI  - Unraveling Ras Interactions
AID  - 10.1126/stke.4092007tw382
DP  - 2007 Oct 23
TA  - Science's STKE
PG  - tw382--tw382
VI  - 2007
IP  - 409
4099  - http://stke.sciencemag.org/content/2007/409/tw382.short
4100  - http://stke.sciencemag.org/content/2007/409/tw382.full
SO  - Sci. STKE2007 Oct 23; 2007
AB  - Activated signaling through the small guanosine triphosphatase Ras is often associated with abnormal proliferation of cancer cells. Stites et al. used a combination of mathematical modeling and experiments to gain new insights into the regulatory properties of the network of factors that influence Ras (or are regulated by it) and how these factors are altered in cancer cells. Their results offer insight into why particular activating Ras mutants, but not others, are found in cancer cells, and suggest a pharmacological strategy that may preferentially impede excessive signaling in networks containing an oncogenically mutated form of Ras while sparing normal cells. E. C. Stites, P. C. Trampont, Z. Ma, K. S. Ravichandran, Network analysis of oncogenic Ras activation in cancer. Science 318, 463-467 (2007). [Abstract] [Full Text]