RT Journal Article
SR Electronic
T1 Novel Roles for the NF-κB Signaling Pathway in Regulating Neuronal Function
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP pe7
OP pe7
DO 10.1126/stke.16pe7
VO 1
IS 6
A1 Boersma, Matt C.
A1 Meffert, Mollie K.
YR 2008
UL http://stke.sciencemag.org/content/1/6/pe7.abstract
AB Two new reports offer exciting evidence of novel roles for components of the nuclear factor κB (NF-κB) pathway in the nervous system. Transcriptional activation by NF-κB and chromatin remodeling by inhibitor of κB (IκB) kinase complex (IKK) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system. In the Drosophila neuromuscular junction, a member of the NF-κB family has been reported to regulate glutamate receptor clustering. Both reports could have important implications for the function of the NF-κB signaling pathway in neuronal plasticity.