RT Journal Article
SR Electronic
T1 Life and Death Decisions
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw412
OP tw412
DO 10.1126/stke.4122007tw412
VO 2007
IS 412
A1 Hurtley, Stella M.
YR 2007
UL http://stke.sciencemag.org/content/2007/412/tw412.abstract
AB How do cells determine whether to live or die after exposure to stressors that cause misfolding of intracellular proteins? Lin et al. find that the IRE1 signaling branch of the unfolded protein response plays a key role in promoting cell survival after protein misfolding in the endoplasmic reticulum (ER). Human cells shut off IRE1 signaling after prolonged ER protein misfolding in order to enhance cell survival. J. H. Lin, H. Li, D. Yasumura, H. R. Cohen, C. Zhang, B. Panning, K. M. Shokat, M. M. LaVail, P. Walter, IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949 (2007). [Abstract] [Full Text]