RT Journal Article SR Electronic T1 Life and Death Decisions JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP tw412 OP tw412 DO 10.1126/stke.4122007tw412 VO 2007 IS 412 A1 Hurtley, Stella M. YR 2007 UL http://stke.sciencemag.org/content/2007/412/tw412.abstract AB How do cells determine whether to live or die after exposure to stressors that cause misfolding of intracellular proteins? Lin et al. find that the IRE1 signaling branch of the unfolded protein response plays a key role in promoting cell survival after protein misfolding in the endoplasmic reticulum (ER). Human cells shut off IRE1 signaling after prolonged ER protein misfolding in order to enhance cell survival. J. H. Lin, H. Li, D. Yasumura, H. R. Cohen, C. Zhang, B. Panning, K. M. Shokat, M. M. LaVail, P. Walter, IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949 (2007). [Abstract] [Full Text]