RT Journal Article
SR Electronic
T1 A New Look at an Old Problem: The Survival and Organ-Specific Growth of Metastases
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe3
OP pe3
DO 10.1126/stke.2162004pe3
VO 2004
IS 216
A1 Vander Griend, Donald J.
A1 Rinker-Schaeffer, Carrie W.
YR 2004
UL http://stke.sciencemag.org/content/2004/216/pe3.abstract
AB Despite improvements in cancer detection and therapy, metastatic disease is largely incurable. Recent research indicates that tumor cells disseminate widely early in the process of pathogenesis, and that the survival and proliferation of these cells--and thus the development of metastases--depend on interactions between the disseminated cells and their particular microenvironment. Proliferative signals and the inhibition of proapoptotic responses are both critically involved in the development of clinically significant metastases. Identification of the underlying signaling cascades may provide additional targets for antimetastatic therapy.