RT Journal Article SR Electronic T1 A New Look at an Old Problem: The Survival and Organ-Specific Growth of Metastases JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP pe3 OP pe3 DO 10.1126/stke.2162004pe3 VO 2004 IS 216 A1 Vander Griend, Donald J. A1 Rinker-Schaeffer, Carrie W. YR 2004 UL http://stke.sciencemag.org/content/2004/216/pe3.abstract AB Despite improvements in cancer detection and therapy, metastatic disease is largely incurable. Recent research indicates that tumor cells disseminate widely early in the process of pathogenesis, and that the survival and proliferation of these cells--and thus the development of metastases--depend on interactions between the disseminated cells and their particular microenvironment. Proliferative signals and the inhibition of proapoptotic responses are both critically involved in the development of clinically significant metastases. Identification of the underlying signaling cascades may provide additional targets for antimetastatic therapy.