RT Journal Article
SR Electronic
T1 Nuclear Receptors: The Evolution of Diversity
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe4
OP pe4
DO 10.1126/stke.2172004pe4
VO 2004
IS 217
A1 Schwabe, John W. R.
A1 Teichmann, Sarah A.
YR 2004
UL http://stke.sciencemag.org/content/2004/217/pe4.abstract
AB Nuclear receptors are an ancient family of transcription factors. Some receptors are regulated by small lipophilic ligands, whereas others are constitutive transcriptional activators or repressors. The evolution of this diversity is poorly understood, and it remains an open question as to whether or not the ancestral receptor was ligand-regulated. The recent cloning, from a snail, of an estrogen receptor that does not bind estrogen not only suggests that the steroid receptors are much more ancient than previous thought, but also points toward a mechanism through which nuclear receptors can lose the ability to be ligand regulated.