PT  - JOURNAL ARTICLE
AU  - Kutscher, Brett
AU  - Devreotes, Peter
AU  - Iglesias, Pablo A.
TI  - Local Excitation, Global Inhibition Mechanism for Gradient Sensing: An Interactive Applet
AID  - 10.1126/stke.2192004pl3
DP  - 2004 Feb 10
TA  - Science's STKE
PG  - pl3--pl3
VI  - 2004
IP  - 219
4099  - http://stke.sciencemag.org/content/2004/219/pl3.short
4100  - http://stke.sciencemag.org/content/2004/219/pl3.full
SO  - Sci. STKE2004 Feb 10; 2004
AB  - We have proposed a model in which cells detect gradients of chemoattractant by balancing a fast local excitation and a slower global inhibition. To illustrate this general mechanism, we have developed an interactive applet that mimics laboratory experiments in which either spatially homogeneous or heterogeneous stimuli of chemoattractant are applied.