RT Journal Article
SR Electronic
T1 Local Excitation, Global Inhibition Mechanism for Gradient Sensing: An Interactive Applet
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pl3
OP pl3
DO 10.1126/stke.2192004pl3
VO 2004
IS 219
A1 Kutscher, Brett
A1 Devreotes, Peter
A1 Iglesias, Pablo A.
YR 2004
UL http://stke.sciencemag.org/content/2004/219/pl3.abstract
AB We have proposed a model in which cells detect gradients of chemoattractant by balancing a fast local excitation and a slower global inhibition. To illustrate this general mechanism, we have developed an interactive applet that mimics laboratory experiments in which either spatially homogeneous or heterogeneous stimuli of chemoattractant are applied.