PT  - JOURNAL ARTICLE
AU  - van Amerongen, Renée
AU  - Mikels, Amanda
AU  - Nusse, Roel
TI  - Alternative Wnt Signaling Is Initiated by Distinct Receptors
AID  - 10.1126/scisignal.135re9
DP  - 2008 Sep 02
TA  - Science Signaling
PG  - re9--re9
VI  - 1
IP  - 35
4099  - http://stke.sciencemag.org/content/1/35/re9.short
4100  - http://stke.sciencemag.org/content/1/35/re9.full
SO  - Sci. Signal.2008 Sep 02; 1
AB  - An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.