PT - JOURNAL ARTICLE AU - Olson, Mark O. J. TI - Sensing Cellular Stress: Another New Function for the Nucleolus? AID - 10.1126/stke.2242004pe10 DP - 2004 Mar 16 TA - Science's STKE PG - pe10--pe10 VI - 2004 IP - 224 4099 - http://stke.sciencemag.org/content/2004/224/pe10.short 4100 - http://stke.sciencemag.org/content/2004/224/pe10.full SO - Sci. STKE2004 Mar 16; 2004 AB - Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.