PT  - JOURNAL ARTICLE
AU  - Olson, Mark O. J.
TI  - Sensing Cellular Stress: Another New Function for the Nucleolus?
AID  - 10.1126/stke.2242004pe10
DP  - 2004 Mar 16
TA  - Science's STKE
PG  - pe10--pe10
VI  - 2004
IP  - 224
4099  - http://stke.sciencemag.org/content/2004/224/pe10.short
4100  - http://stke.sciencemag.org/content/2004/224/pe10.full
SO  - Sci. STKE2004 Mar 16; 2004
AB  - Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.