RT Journal Article SR Electronic T1 Sensing Cellular Stress: Another New Function for the Nucleolus? JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP pe10 OP pe10 DO 10.1126/stke.2242004pe10 VO 2004 IS 224 A1 Olson, Mark O. J. YR 2004 UL http://stke.sciencemag.org/content/2004/224/pe10.abstract AB Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.