RT Journal Article
SR Electronic
T1 Sensing Cellular Stress: Another New Function for the Nucleolus?
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe10
OP pe10
DO 10.1126/stke.2242004pe10
VO 2004
IS 224
A1 Olson, Mark O. J.
YR 2004
UL http://stke.sciencemag.org/content/2004/224/pe10.abstract
AB Recent research suggests that the nucleolus communicates with the p53 regulatory system and acts as a stress sensor. Cellular stress causes nucleolar disruption, triggering the release of regulatory factors to the nucleoplasm. These factors, especially ARF (alternative reading frame), inhibit the degradation of p53, thereby facilitating its intracellular accumulation.