PT - JOURNAL ARTICLE AU - Janardhan, Harish P. TI - The HIF-1α–C/EBPα Axis AID - 10.1126/scisignal.143jc2 DP - 2008 Oct 28 TA - Science Signaling PG - jc2--jc2 VI - 1 IP - 43 4099 - http://stke.sciencemag.org/content/1/43/jc2.short 4100 - http://stke.sciencemag.org/content/1/43/jc2.full SO - Sci. Signal.2008 Oct 28; 1 AB - The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBPα) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1α and C/EBPα interact, they bring about reciprocal functional changes, so that the activity of HIF-1α is decreased and that of C/EBPα is restricted or increased in a tissue-specific manner. This Journal Club article highlights research depicting interactions between HIF-1α and C/EBPα and discusses conditions and tissues in which this interaction might occur.