PT  - JOURNAL ARTICLE
AU  - Janardhan, Harish P.
TI  - The HIF-1α–C/EBPα Axis
AID  - 10.1126/scisignal.143jc2
DP  - 2008 Oct 28
TA  - Science Signaling
PG  - jc2--jc2
VI  - 1
IP  - 43
4099  - http://stke.sciencemag.org/content/1/43/jc2.short
4100  - http://stke.sciencemag.org/content/1/43/jc2.full
SO  - Sci. Signal.2008 Oct 28; 1
AB  - The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBPα) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1α and C/EBPα interact, they bring about reciprocal functional changes, so that the activity of HIF-1α is decreased and that of C/EBPα is restricted or increased in a tissue-specific manner. This Journal Club article highlights research depicting interactions between HIF-1α and C/EBPα and discusses conditions and tissues in which this interaction might occur.