PT  - JOURNAL ARTICLE
ED  - , 
TI  - Patterning the Frontal Lobe
AID  - 10.1126/stke.2262004TW118
DP  - 2004 Mar 30
TA  - Science's STKE
PG  - tw118--TW118
VI  - 2004
IP  - 226
4099  - http://stke.sciencemag.org/content/2004/226/tw118.short
4100  - http://stke.sciencemag.org/content/2004/226/tw118.full
SO  - Sci. STKE2004 Mar 30; 2004
AB  - Regions of the frontal lobe are essential for higher cognitive function. In patients with bilateral frontoparietal polymicrogyria (BFPP), affected individuals show frontal lobe dysfunction (including mental retardation, gait difficulty, language delay, and seizures) and characteristic frontal lobe anatomy (bilaterally symmetrical, and abnormally thin with multiple small, irregular folds). Piao et al. (see Perspective by Holt and Jahn) identify the genetic basis of BFPP as mutations in a putative G protein-coupled receptor, GPR56. GPR56 appears primarily to affect neuronal progenitors and, thus, regional patterning of human cerebral cortex. X. Piao, R. S. Hill, A. Bodell, B. S. Chang, L. Basel-Vanagaite, R. Straussberg, W. B. Dobyns, B. Qasrawi, R. M. Winter, A. M. Innes, T. Voit, M. E. Ross, J. L. Michaud, J.-C. Déscarie, A. J. Barkovich, C. A. Walsh, G protein-coupled receptor-dependent development of human frontal cortex. Science 303, 2033-2036 (2004). [Abstract] [Full Text] P. Rakic, Genetic control of cortical convolutions. Science 303, 1983-1984 (2004). [Summary] [Full Text]