PT - JOURNAL ARTICLE AU - Merlo, Adrian AU - Bettler, Bernhard TI - Glioblastomas on the Move AID - 10.1126/stke.2292004pe18 DP - 2004 Apr 20 TA - Science's STKE PG - pe18--pe18 VI - 2004 IP - 229 4099 - http://stke.sciencemag.org/content/2004/229/pe18.short 4100 - http://stke.sciencemag.org/content/2004/229/pe18.full SO - Sci. STKE2004 Apr 20; 2004 AB - The mechanism by which the tumor suppressor PTEN slows tumor cell migration is not well characterized. A recent study by Raftopoulou et al. shows that a lack of PTEN protein phosphatase activity accelerates the migration of glioblastoma cells. The protein phosphatase activity of PTEN is directly or indirectly responsible for dephosphorylating a PTEN residue, threonine-383, which is necessary for slowing cell migration. These findings have implications for the design of new therapies against glioblastomas and other highly invasive cancers.