PT  - JOURNAL ARTICLE
AU  - Merlo, Adrian
AU  - Bettler, Bernhard
TI  - Glioblastomas on the Move
AID  - 10.1126/stke.2292004pe18
DP  - 2004 Apr 20
TA  - Science's STKE
PG  - pe18--pe18
VI  - 2004
IP  - 229
4099  - http://stke.sciencemag.org/content/2004/229/pe18.short
4100  - http://stke.sciencemag.org/content/2004/229/pe18.full
SO  - Sci. STKE2004 Apr 20; 2004
AB  - The mechanism by which the tumor suppressor PTEN slows tumor cell migration is not well characterized. A recent study by Raftopoulou et al. shows that a lack of PTEN protein phosphatase activity accelerates the migration of glioblastoma cells. The protein phosphatase activity of PTEN is directly or indirectly responsible for dephosphorylating a PTEN residue, threonine-383, which is necessary for slowing cell migration. These findings have implications for the design of new therapies against glioblastomas and other highly invasive cancers.