PT - JOURNAL ARTICLE AU - Major, Michael B. AU - Moon, Randall T. TI - “Omic” Risk Assessment AID - 10.1126/scisignal.272eg7 DP - 2009 May 26 TA - Science Signaling PG - eg7--eg7 VI - 2 IP - 72 4099 - http://stke.sciencemag.org/content/2/72/eg7.short 4100 - http://stke.sciencemag.org/content/2/72/eg7.full SO - Sci. Signal.2009 May 26; 2 AB - Integration of data from different techniques is the key to effective validation of “hits” in large-scale screens. A discussion of validation methods for siRNA screens and protein-interaction screens reveals how to go beyond an arbitrary assignment of relevant to a more biologically meaningful identification of targets.