PT  - JOURNAL ARTICLE
AU  - Snyder, Peter M.
TI  - Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2
AID  - 10.1126/scisignal.279pe41
DP  - 2009 Jul 14
TA  - Science Signaling
PG  - pe41--pe41
VI  - 2
IP  - 79
4099  - http://stke.sciencemag.org/content/2/79/pe41.short
4100  - http://stke.sciencemag.org/content/2/79/pe41.full
SO  - Sci. Signal.2009 Jul 14; 2
AB  - E3 ubiquitin ligases catalyze ubiquitination, which can target specific proteins for degradation. Although a growing number of E3 ubiquitin ligases and their targets have been identified, much less is known about the mechanisms that regulate their activity. A convergence of data indicate that phosphorylation regulates the binding of Nedd4-2, a HECT (homologous to the E6-AP C terminus) domain E3 ubiquitin ligase, to its target, the epithelial Na+ channel ENaC. Nedd4-2 phosphorylation is emerging as a central convergence point for the regulation of epithelial Na+ transport.