PT - JOURNAL ARTICLE AU - Snyder, Peter M. TI - Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2 AID - 10.1126/scisignal.279pe41 DP - 2009 Jul 14 TA - Science Signaling PG - pe41--pe41 VI - 2 IP - 79 4099 - http://stke.sciencemag.org/content/2/79/pe41.short 4100 - http://stke.sciencemag.org/content/2/79/pe41.full SO - Sci. Signal.2009 Jul 14; 2 AB - E3 ubiquitin ligases catalyze ubiquitination, which can target specific proteins for degradation. Although a growing number of E3 ubiquitin ligases and their targets have been identified, much less is known about the mechanisms that regulate their activity. A convergence of data indicate that phosphorylation regulates the binding of Nedd4-2, a HECT (homologous to the E6-AP C terminus) domain E3 ubiquitin ligase, to its target, the epithelial Na+ channel ENaC. Nedd4-2 phosphorylation is emerging as a central convergence point for the regulation of epithelial Na+ transport.