PT  - JOURNAL ARTICLE
AU  - Rajakulendran, Thanashan
AU  - Sicheri, Frank
TI  - Allosteric Protein Kinase Regulation by Pseudokinases: Insights from STRAD
AID  - 10.1126/scisignal.3111pe8
DP  - 2010 Mar 02
TA  - Science Signaling
PG  - pe8--pe8
VI  - 3
IP  - 111
4099  - http://stke.sciencemag.org/content/3/111/pe8.short
4100  - http://stke.sciencemag.org/content/3/111/pe8.full
SO  - Sci. Signal.2010 Mar 02; 3
AB  - Protein kinases regulate a plethora of diverse cellular functions. Their highly controlled activation is subject to an equally diverse repertoire of regulatory mechanisms. Pseudokinases, a class of proteins that possess a structurally related protein kinase domain that lacks phospho-transfer function, are emerging as critical yet mysterious regulators of other protein kinases. A new structural and functional analysis of the pseudokinase STRAD provides insight into the mechanism by which it allosterically regulates the catalytic function of the protein kinase LKB1 and hints at an evolution from a classical kinase-substrate relationship.