RT Journal Article
SR Electronic
T1 No Genetic Vertigo
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP ec207
OP ec207
DO 10.1126/scisignal.3129ec207
VO 3
IS 129
A1 Zahn, Laura M.
YR 2010
UL http://stke.sciencemag.org/content/3/129/ec207.abstract
AB Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz). To identify gene regions that might have contributed to high-altitude adaptation in Tibetans, Simonson et al. conducted a genome scan of nucleotide polymorphism comparing Tibetans, Han Chinese, and Japanese, while Yi et al. performed comparable analyses on the coding regions of all genes—their exomes. Both studies converged on a gene, endothelial PAS domain protein 1 (also known as hypoxia-inducible factor 2α), which has been linked to the regulation of red blood cell production. Other genes identified that were potentially under selection included adult and fetal hemoglobin and two functional candidate loci that were correlated with low hemoglobin concentration in Tibetans. Future detailed functional studies will now be required to examine the mechanistic underpinnings of physiological adaptation to high altitudes. T. S. Simonson, Y. Yang, C. D. Huff, H. Yun, G. Qin, D. J. Witherspoon, Z. Bai, F. R. Lorenzo, J. Xing, L. B. Jorde, J. T. Prchal, R. Ge, Genetic evidence for high-altitude adaptation in Tibet. Science 329, 72–75 (2010). [Abstract] [Full Text] X. Yi, Y. Liang, E. Huerta-Sanchez, X. Jin, Z. X. P. Cuo, J. E. Pool, X. Xu, H. Jiang, N. Vinckenbosch, T. S. Korneliussen, H. Zheng, T. Liu, W. He, K. Li, R. Luo, X. Nie, H. Wu, M. Zhao, H. Cao, J. Zou, Y. Shan, S. Li, Q. Yang, Asan, P. Ni, G. Tian, J. Xu, X. Liu, T. Jiang, R. Wu, G. Zhou, M. Tang, J. Qin, T. Wang, S. Feng, G. Li, Huasang, J. Luosang, W. Wang, F. Chen, Y. Wang, X. Zheng, Z. Li, Z. Bianba, G. Yang, X. Wang, S. Tang, G. Gao, Y. Chen, Z. Luo, L. Gusang, Z. Cao, Q. Zhang, W. Ouyang, X. Ren, H. Liang, H. Zheng, Y. Huang, J. Li, L. Bolund, K. Kristiansen, Y. Li, Y. Zhang, X. Zhang, R. Li, S. Li, H. Yang, R. Nielsen, J. Wang, J. Wang, Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329, 75–78 (2010). [Abstract] [Full Text] J. F. Storz, Genes for high altitudes. Science 329, 40–41 (2010). [Abstract] [Full Text]