PT - JOURNAL ARTICLE AU - Adler, Elizabeth M. TI - 2008: Signaling Breakthroughs of the Year AID - 10.1126/scisignal.252eg1 DP - 2009 Jan 06 TA - Science Signaling PG - eg1--eg1 VI - 2 IP - 52 4099 - http://stke.sciencemag.org/content/2/52/eg1.short 4100 - http://stke.sciencemag.org/content/2/52/eg1.full SO - Sci. Signal.2009 Jan 06; 2 AB - This year's signaling breakthroughs extended from protein crystals to cells and subcellular structures to whole genomes. Nominations included research on synapses in brains and in B cells; the evolution and regulation of signaling networks; the identification of a new class of plant hormones; insights into the causes and treatments of disease, such as cancer and schizophrenia; and a possible way to stay in shape while avoiding exercise.