RT Journal Article
SR Electronic
T1 G Protein–Coupled Receptors in Child Development, Growth, and Maturation
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP re7
OP re7
DO 10.1126/scisignal.3143re7
VO 3
IS 143
A1 Latronico, Ana Claudia
A1 Hochberg, Ze’ev
YR 2010
UL http://stke.sciencemag.org/content/3/143/re7.abstract
AB G protein–coupled receptors (GPCRs) constitute a large family of cell membrane receptors that affect embryogenesis, development, and child physiology, and they are targets for approved drugs and those still in development. The sensitivity of GPCRs to their respective extracellular hormones, neurotransmitters, and environmental stimulants, as well as their interaction with other receptors and intracellular signaling proteins (such as receptor activity–modifying proteins), contribute to variations in child development, growth, and maturation. Here, we summarize current knowledge about the mechanisms of activation (in either the presence or absence of ligands) that lead to the sensitivities of GPCRs and their respective effects as seen throughout human developmental and maturational phases.