RT Journal Article SR Electronic T1 Role of Syntaxin 4 in Activity-Dependent Exocytosis and Synaptic Plasticity in Hippocampal Neurons JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP jc7 OP jc7 DO 10.1126/scisignal.3144jc7 VO 3 IS 144 A1 Mohanasundaram, Ponnuswamy A1 Shanmugam, Muniesh Muthaiyan YR 2010 UL http://stke.sciencemag.org/content/3/144/jc7.abstract AB Activity-dependent exocytosis of recycling endosomes that contain AMPA receptors in postsynaptic regions of hippocampal neurons occurs at microdomains enriched in the target SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor] syntaxin 4 (Stx4). These Stx4-enriched domains are located near the postsynaptic density, and disrupting SNARE interactions involving Stx4 prevents the fusion of recycling endosomes that contain AMPA receptors in dendritic spines. AMPA receptor trafficking is important for long-term potentiation; thus, Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons.