RT Journal Article
SR Electronic
T1 Role of Syntaxin 4 in Activity-Dependent Exocytosis and Synaptic Plasticity in Hippocampal Neurons
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP jc7
OP jc7
DO 10.1126/scisignal.3144jc7
VO 3
IS 144
A1 Mohanasundaram, Ponnuswamy
A1 Shanmugam, Muniesh Muthaiyan
YR 2010
UL http://stke.sciencemag.org/content/3/144/jc7.abstract
AB Activity-dependent exocytosis of recycling endosomes that contain AMPA receptors in postsynaptic regions of hippocampal neurons occurs at microdomains enriched in the target SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor] syntaxin 4 (Stx4). These Stx4-enriched domains are located near the postsynaptic density, and disrupting SNARE interactions involving Stx4 prevents the fusion of recycling endosomes that contain AMPA receptors in dendritic spines. AMPA receptor trafficking is important for long-term potentiation; thus, Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons.