RT Journal Article
SR Electronic
T1 Grab Your Partner with Both Hands: Cytoskeletal Remodeling by Arp2/3 Signaling
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP pe5
OP pe5
DO 10.1126/scisignal.255pe5
VO 2
IS 55
A1 Soderling, Scott H.
YR 2009
UL http://stke.sciencemag.org/content/2/55/pe5.abstract
AB The seemingly simple structure of the actin filament belies the elaborate signaling pathways that regulate its assembly and disassembly in eukaryotic cells. In retrospect, this signaling complexity should not be surprising. Actin regulates many dynamic cellular processes, including protein and organelle trafficking, establishment of cell polarity, directional migration, cellular traction, and the efficiency of endocytosis. Signaling events that coordinately control actin turnover during these processes must display a high degree of sophistication. Emerging data on an important regulator of actin dynamics, the actin-related protein 2 and 3 (Arp2/3) complex, suggest a model of how this may occur.