PT  - JOURNAL ARTICLE
AU  - Mueller, Kristen L.
TI  - Skin Reaction
AID  - 10.1126/scisignal.3138ec273
DP  - 2010 Sep 07
TA  - Science Signaling
PG  - ec273--ec273
VI  - 3
IP  - 138
4099  - http://stke.sciencemag.org/content/3/138/ec273.short
4100  - http://stke.sciencemag.org/content/3/138/ec273.full
SO  - Sci. Signal.2010 Sep 07; 3
AB  - Lymphocytes in the skin known as γδ T cells provide an important barrier against infection and injury. Unlike classical αβ T cells, less is known about the molecular requirements of γδ T cell activation. Two studies demonstrate that the junctional adhesion molecule–like protein (JAML) is a costimulatory molecule for mouse γδ T cells. Witherden et al. (see the Perspective by Shaw and Huang) showed that JAML, binding to its ligand Coxsackie and adenovirus receptor (CAR), leads to proliferation, as well as cytokine and growth factor production by γδ T cells. In vivo, JAML-CAR interactions contributed to the wound-healing response in mice. Verdino et al. (see the Perspective by Shaw and Huang) present a crystal structure of CAR/JAML, which reveals an intracellular signaling motif similar to that known for the αβ T cell costimulatory receptor that signals through phosphoinositide 3-kinase. D. A. Witherden, P. Verdino, S. E. Rieder, O. Garijo, R. E. Mills, L. Teyton, W. H. Fischer, I. A. Wilson, W. L. Havran, The junctional adhesion molecule JAML is a costimulatory receptor for epithelial γδ T cell activation. Science 329, 1205–1210 (2010). [Abstract] [Full Text] P. Verdino, D. A. Witherden, W. L. Havran, I. A. Wilson, The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science 329, 1210–1214 (2010). [Abstract] [Full Text] A. S. Shaw, Y. Huang, CAR’ing for the skin. Science 329, 1154–1155 (2010). [Summary] [Full Text]