PT  - JOURNAL ARTICLE
AU  - Su, Tsung-Ping
AU  - Hayashi, Teruo
AU  - Vaupel, D. Bruce
TI  - When the Endogenous Hallucinogenic Trace Amine <em>N,N</em>-Dimethyltryptamine Meets the Sigma-1 Receptor
AID  - 10.1126/scisignal.261pe12
DP  - 2009 Mar 10
TA  - Science Signaling
PG  - pe12--pe12
VI  - 2
IP  - 61
4099  - http://stke.sciencemag.org/content/2/61/pe12.short
4100  - http://stke.sciencemag.org/content/2/61/pe12.full
SO  - Sci. Signal.2009 Mar 10; 2
AB  - N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors.