RT Journal Article
SR Electronic
T1 Muscle Building
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP ec382
OP ec382
DO 10.1126/scisignal.3152ec382
VO 3
IS 152
A1 Hurtley, Stella M.
YR 2010
UL http://stke.sciencemag.org/content/3/152/ec382.abstract
AB The signaling mechanisms involved in actin filament formation for myofibril formation, which is required for growth factor–induced muscle maturation and hypertrophy, remain unclear. Takano et al. (see the Perspective by Gautel and Ehler) now show that the mechanism involves the interaction of nebulin and N-WASP. N-WASP is an activator of the Arp2/3 complex, which induces branched actin filaments in nonmuscle cells. The nebulin–N-WASP complex formed in muscle, however, causes nucleation of unbranched actin filaments within myofibrils without the Arp2/3 complex. Nebulin–N-WASP–mediated myofibrillar actin filament formation is required for muscle hypertrophy and might explain a congenital hereditary neuromuscular disorder caused by nebulin gene mutation: nemaline myopathy. K. Takano, H. Watanabe-Takano, S. Suetsugu, S. Kurita, K. Tsujita, S. Kimura, T. Karatsu, T. Takenawa, T. Endo, Nebulin and N-WASP cooperate to cause IGF-1–induced sarcomeric actin filament formation. Science 330, 1536–1540 (2010). [Abstract] [Full Text] M. Gautel, E. Ehler, Gett'N-WASP stripes. Science 330, 1491–1492 (2010). [Abstract] [Full Text]