PT  - JOURNAL ARTICLE
AU  - Mehlen, Patrick
AU  - Bredesen, Dale E.
TI  - Dependence Receptors: From Basic Research to Drug Development
AID  - 10.1126/scisignal.2001521
DP  - 2011 Jan 25
TA  - Science Signaling
PG  - mr2--mr2
VI  - 4
IP  - 157
4099  - http://stke.sciencemag.org/content/4/157/mr2.short
4100  - http://stke.sciencemag.org/content/4/157/mr2.full
SO  - Sci. Signal.2011 Jan 25; 4
AB  - The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012.