PT - JOURNAL ARTICLE AU - Mehlen, Patrick AU - Bredesen, Dale E. TI - Dependence Receptors: From Basic Research to Drug Development AID - 10.1126/scisignal.2001521 DP - 2011 Jan 25 TA - Science Signaling PG - mr2--mr2 VI - 4 IP - 157 4099 - http://stke.sciencemag.org/content/4/157/mr2.short 4100 - http://stke.sciencemag.org/content/4/157/mr2.full SO - Sci. Signal.2011 Jan 25; 4 AB - The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012.