RT Journal Article
SR Electronic
T1 Dependence Receptors: From Basic Research to Drug Development
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP mr2
OP mr2
DO 10.1126/scisignal.2001521
VO 4
IS 157
A1 Mehlen, Patrick
A1 Bredesen, Dale E.
YR 2011
UL http://stke.sciencemag.org/content/4/157/mr2.abstract
AB The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012.