PT  - JOURNAL ARTICLE
AU  - Pan, Fan
AU  - Fan, Huimin
AU  - Lu, Ling
AU  - Liu, Zhongmin
AU  - Jiang, Shuiping
TI  - The Yin and Yang of Signaling in T<sub>regs</sub> and T<sub>H</sub>17 Cells
AID  - 10.1126/scisignal.2001709
DP  - 2011 Mar 22
TA  - Science Signaling
PG  - mr4--mr4
VI  - 4
IP  - 165
4099  - http://stke.sciencemag.org/content/4/165/mr4.short
4100  - http://stke.sciencemag.org/content/4/165/mr4.full
SO  - Sci. Signal.2011 Mar 22; 4
AB  - A report on the Second International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases: “China Tregs/Th17 2010 Shanghai Conference,” Shanghai, China, 17 to 20 July 2010. Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (Tregs) and T helper 17 (TH17) cells and their potential clinical applications have been made. In response to these breakthroughs, the second international conference entitled “China Tregs/Th17 2010 Shanghai Conference,” held in Shanghai, China, was dedicated to this topic. Various types of Tregs and TH17 cells, as well as their relevant cytokines, were discussed. Here, we summarize some of the findings shared at the conference, specifically focusing on the biology of TH17 cells, including interleukin-17 (IL-17)–producing innate cells, Tregs, and the factors that control the critical balance between Tregs and cells of the TH17 lineage.