PT  - JOURNAL ARTICLE
AU  - Hoffmann, Alexander
AU  - VanHook, Annalisa M.
TI  - <em>Science Signaling</em> Podcast: 22 February 2011
AID  - 10.1126/scisignal.2001898
DP  - 2011 Feb 22
TA  - Science Signaling
PG  - pc3--pc3
VI  - 4
IP  - 161
4099  - http://stke.sciencemag.org/content/4/161/pc3.short
4100  - http://stke.sciencemag.org/content/4/161/pc3.full
SO  - Sci. Signal.2011 Feb 22; 4
AB  - This is a conversation with Alexander Hoffmann about a Research Article published in the 22 February 2011 issue of Science Signaling. Hoffmann discusses his group’s report on how homodimers of the nuclear factor κB (NF-κB) p50 regulate the innate immune response. The study revealed that NF-κB homodimers compete with interferon regulatory factors (IRFs) for binding to guanine-rich interferon response elements (G-IREs) to restrict the activation of antiviral genes to only the appropriate stimuli.