RT Journal Article
SR Electronic
T1 Sizing Signals
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP ec70
OP ec70
DO 10.1126/scisignal.4163ec70
VO 4
IS 163
A1 Hurtley, Stella M.
YR 2011
UL http://stke.sciencemag.org/content/4/163/ec70.abstract
AB Growth regulation of the Drosophila wing imaginal disc critically depends on the Decapentaplegic (Dpp) morphogen gradient. How a graded Dpp signal is interpreted by cells to control homogeneous tissue growth remains unclear. Wartlick et al. (see the Perspective by Le Goff and Lecuit) address this question by measuring the spatial and temporal changes of Dpp concentration and signaling activity during the disc growth phase and by quantifying cell proliferation parameters in the discs. Both modeling and experimental findings suggest that both Dpp concentration and signaling gradients scale with tissue size so that, on average, the onset of mitosis occurs when Dpp signaling levels have increased by 50% since the beginning of the cell cycle. O. Wartlick, P. Mumcu, A. Kicheva, T. Bittig, C. Seum, F. Jülicher, M. González-Gaitán, Dynamics of Dpp signaling and proliferation control. Science 331, 1154–1159 (2011). [Abstract] [Full Text] L. Le Goff, T. Lecuit, Gradient scaling and growth. Science 331, 1141–1142 (2011). [Abstract] [Full Text]