PT - JOURNAL ARTICLE AU - Ray, L. Bryan TI - Feeling the Heat AID - 10.1126/scisignal.4164ec76 DP - 2011 Mar 15 TA - Science Signaling PG - ec76--ec76 VI - 4 IP - 164 4099 - http://stke.sciencemag.org/content/4/164/ec76.short 4100 - http://stke.sciencemag.org/content/4/164/ec76.full SO - Sci. Signal.2011 Mar 15; 4 AB - Given a choice, a fruit fly will seek a temperature optimum of 18°C. This behavior requires a biochemical signaling pathway apparently initiated by a heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptor. Given the similarity of these signaling events to those initiated by rhodopsin, the G protein–coupled receptor that senses light, Shen et al. (see the Perspective by Minke and Peters) tested the effects of rhodopsin mutations on temperature selection in flies and, surprisingly, found that it resulted in discrimination between temperatures within a few degrees of the optimal 18°C, independent of light sensation. One or more accessory molecules may also be required, as the rhodopsin molecule itself does not seem to be the temperature sensor. W. L. Shen, Y. Kwon, A. A. Adegbola, J. Luo, A. Chess, C. Montell, Function of rhodopsin in temperature discrimination in Drosophila. Science 331, 1333–1336 (2011). [Abstract] [Full Text] B. Minke, M. Peters, Rhodopsin as thermosensor? Science 331, 1272–1273 (2011). [Abstract] [Full Text]