RT Journal Article
SR Electronic
T1 <em>Science Signaling</em> Podcast: 25 October 2011
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP pc22
OP pc22
DO 10.1126/scisignal.2002560
VO 4
IS 196
A1 Friedman, Adam A.
A1 Perrimon, Norbert
A1 VanHook, Annalisa M.
YR 2011
UL http://stke.sciencemag.org/content/4/196/pc22.abstract
AB This Podcast features a conversation with authors of a Research Resource published in the 25 October 2011 issue of Science Signaling. Although the extracellular signal–regulated kinase (ERK) pathway has been extensively studied, our understanding of all the regulatory interactions that modulate signaling is by no means complete. Adam Friedman and Norbert Perrimon discuss their group’s strategy of combining functional and genomics approaches to identify common and specific regulators of ERK signaling in the fruit fly Drosophila melanogaster. The ERK pathway plays an important role in normal developmental and physiological contexts as well as in disease states, such as tumorigenesis.