PT  - JOURNAL ARTICLE
AU  - Li, Xiaoxia
AU  - VanHook, Annalisa M.
TI  - <em>Science Signaling</em> Podcast: 1 November 2011
AID  - 10.1126/scisignal.2002614
DP  - 2011 Nov 01
TA  - Science Signaling
PG  - pc23--pc23
VI  - 4
IP  - 197
4099  - http://stke.sciencemag.org/content/4/197/pc23.short
4100  - http://stke.sciencemag.org/content/4/197/pc23.full
SO  - Sci. Signal.2011 Nov 01; 4
AB  - This Podcast features a conversation with the senior author of a Research Article published in the 1 November 2011 issue of Science Signaling. Xiaoxia Li discusses her group’s identification of a region within the adaptor protein Act1 that is critical for its binding to the proinflammatory Interleukin-17 receptor. They designed a cell-permeable peptide that can bind to the receptor and inhibit its signaling, thus reducing inflammation, in a mouse model. Similar strategies might be successful in developing methods for blocking IL-17-dependent inflammatory disease in humans.