PT - JOURNAL ARTICLE AU - Li, Xiaoxia AU - VanHook, Annalisa M. TI - <em>Science Signaling</em> Podcast: 1 November 2011 AID - 10.1126/scisignal.2002614 DP - 2011 Nov 01 TA - Science Signaling PG - pc23--pc23 VI - 4 IP - 197 4099 - http://stke.sciencemag.org/content/4/197/pc23.short 4100 - http://stke.sciencemag.org/content/4/197/pc23.full SO - Sci. Signal.2011 Nov 01; 4 AB - This Podcast features a conversation with the senior author of a Research Article published in the 1 November 2011 issue of Science Signaling. Xiaoxia Li discusses her group’s identification of a region within the adaptor protein Act1 that is critical for its binding to the proinflammatory Interleukin-17 receptor. They designed a cell-permeable peptide that can bind to the receptor and inhibit its signaling, thus reducing inflammation, in a mouse model. Similar strategies might be successful in developing methods for blocking IL-17-dependent inflammatory disease in humans.