PT - JOURNAL ARTICLE AU - D’Arco, Marianna AU - Dolphin, Annette C. TI - L-Type Calcium Channels: On the Fast Track to Nuclear Signaling AID - 10.1126/scisignal.2003355 DP - 2012 Aug 14 TA - Science Signaling PG - pe34--pe34 VI - 5 IP - 237 4099 - http://stke.sciencemag.org/content/5/237/pe34.short 4100 - http://stke.sciencemag.org/content/5/237/pe34.full SO - Sci. Signal.2012 Aug 14; 5 AB - Calcium signaling resulting from depolarization of neurons can trigger changes in transcription, and this response has been called excitation-transcription (E-T) coupling. In neurons, voltage-gated and ligand-gated calcium-permeable channels contribute to the increase in intracellular calcium. It appears that calcium signals mediated by specific voltage-gated calcium channels may have distinct roles in E-T coupling.