PT  - JOURNAL ARTICLE
AU  - Lin, Chuwen
AU  - Nozawa, Yoko Inès
AU  - Chuang, Pao-Tien
TI  - The Path to Chemotaxis and Transcription Is Smoothened
AID  - 10.1126/scisignal.2003423
DP  - 2012 Aug 21
TA  - Science Signaling
PG  - pe35--pe35
VI  - 5
IP  - 238
4099  - http://stke.sciencemag.org/content/5/238/pe35.short
4100  - http://stke.sciencemag.org/content/5/238/pe35.full
SO  - Sci. Signal.2012 Aug 21; 5
AB  - The Hedgehog (Hh) family of secreted proteins governs the development of numerous tissues by regulating the activity of the Gli family of transcription factors. Emerging evidence shows that Hh also functions as a chemoattractant in several processes through a noncanonical pathway independent of Gli-mediated transcription. How Hh-responsive cells execute transcriptional versus chemotactic responses is a key issue. Data now suggest that altered subcellular localization of the transducer Smoothened, which functions in both the canonical and noncanonical pathways, is responsible for eliciting distinct Hh outputs.