PT - JOURNAL ARTICLE AU - Lin, Chuwen AU - Nozawa, Yoko Inès AU - Chuang, Pao-Tien TI - The Path to Chemotaxis and Transcription Is Smoothened AID - 10.1126/scisignal.2003423 DP - 2012 Aug 21 TA - Science Signaling PG - pe35--pe35 VI - 5 IP - 238 4099 - http://stke.sciencemag.org/content/5/238/pe35.short 4100 - http://stke.sciencemag.org/content/5/238/pe35.full SO - Sci. Signal.2012 Aug 21; 5 AB - The Hedgehog (Hh) family of secreted proteins governs the development of numerous tissues by regulating the activity of the Gli family of transcription factors. Emerging evidence shows that Hh also functions as a chemoattractant in several processes through a noncanonical pathway independent of Gli-mediated transcription. How Hh-responsive cells execute transcriptional versus chemotactic responses is a key issue. Data now suggest that altered subcellular localization of the transducer Smoothened, which functions in both the canonical and noncanonical pathways, is responsible for eliciting distinct Hh outputs.