PT  - JOURNAL ARTICLE
AU  - Ray, L. Bryan
TI  - Silence Please
AID  - 10.1126/scisignal.2003214
DP  - 2012 May 15
TA  - Science Signaling
PG  - ec136--ec136
VI  - 5
IP  - 224
4099  - http://stke.sciencemag.org/content/5/224/ec136.short
4100  - http://stke.sciencemag.org/content/5/224/ec136.full
SO  - Sci. Signal.2012 May 15; 5
AB  - Polycomb group (PcG) proteins play pivotal roles in epigenetic gene control, development, and disease. PcG proteins can control cell cycle progression, but the underlying mechanisms remain unclear. PcG proteins are thought to silence transcription of target genes through modulation of chromatin structure. Mohd-Sarip et al. uncovered an unanticipated transcription-independent function for the canonical PcG protein PSC (Posterior sex combs) in cell cycle control through its direct regulation of cyclin B destruction. A. Mohd-Sarip, A. Lagarou, C. M. Doyen, J. A. van der Knaap, Ü. Aslan, K. Bezstarosti, Y. Yassin, H. W. Brock, J. A. A. Demmers, C. P. Verrijzer, Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science 336, 744–747 (2012). [Abstract] [Full Text]