RT Journal Article
SR Electronic
T1 Silence Please
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP ec136
OP ec136
DO 10.1126/scisignal.2003214
VO 5
IS 224
A1 Ray, L. Bryan
YR 2012
UL http://stke.sciencemag.org/content/5/224/ec136.abstract
AB Polycomb group (PcG) proteins play pivotal roles in epigenetic gene control, development, and disease. PcG proteins can control cell cycle progression, but the underlying mechanisms remain unclear. PcG proteins are thought to silence transcription of target genes through modulation of chromatin structure. Mohd-Sarip et al. uncovered an unanticipated transcription-independent function for the canonical PcG protein PSC (Posterior sex combs) in cell cycle control through its direct regulation of cyclin B destruction. A. Mohd-Sarip, A. Lagarou, C. M. Doyen, J. A. van der Knaap, Ü. Aslan, K. Bezstarosti, Y. Yassin, H. W. Brock, J. A. A. Demmers, C. P. Verrijzer, Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science 336, 744–747 (2012). [Abstract] [Full Text]