PT  - JOURNAL ARTICLE
AU  - Lin, Kui
TI  - The Akt DUBbed InAktive
AID  - 10.1126/scisignal.2003864
DP  - 2013 Jan 08
TA  - Science Signaling
PG  - pe1--pe1
VI  - 6
IP  - 257
4099  - http://stke.sciencemag.org/content/6/257/pe1.short
4100  - http://stke.sciencemag.org/content/6/257/pe1.full
SO  - Sci. Signal.2013 Jan 08; 6
AB  - Akt is a central node in the phosphoinositide-3 kinase–Akt–mammalian target of rapamycin pathway and is activated by a multistep process in response to growth factor stimulation. An additional layer of posttranslational modification has emerged as a new paradigm in the regulation of Akt. The identification of an E3 ligase for Lys63-linked ubiquitination of Akt has now been complemented with the discovery of the tumor suppressor cylindromatosis as a deubiquitinating enzyme (DUB) for Akt. Thus, like phosphorylation and dephosphorylation, cycles of ubiquitination and deubiquitination provide additional on-off switches that keep Akt activity in balance, and disturbances in this balance have pathological consequences.