PT - JOURNAL ARTICLE AU - Lin, Kui TI - The Akt DUBbed InAktive AID - 10.1126/scisignal.2003864 DP - 2013 Jan 08 TA - Science Signaling PG - pe1--pe1 VI - 6 IP - 257 4099 - http://stke.sciencemag.org/content/6/257/pe1.short 4100 - http://stke.sciencemag.org/content/6/257/pe1.full SO - Sci. Signal.2013 Jan 08; 6 AB - Akt is a central node in the phosphoinositide-3 kinase–Akt–mammalian target of rapamycin pathway and is activated by a multistep process in response to growth factor stimulation. An additional layer of posttranslational modification has emerged as a new paradigm in the regulation of Akt. The identification of an E3 ligase for Lys63-linked ubiquitination of Akt has now been complemented with the discovery of the tumor suppressor cylindromatosis as a deubiquitinating enzyme (DUB) for Akt. Thus, like phosphorylation and dephosphorylation, cycles of ubiquitination and deubiquitination provide additional on-off switches that keep Akt activity in balance, and disturbances in this balance have pathological consequences.