PT - JOURNAL ARTICLE AU - Semenza, Gregg L. AU - Hubbi, Maimon E. AU - VanHook, Annalisa M. TI - <em>Science Signaling</em> Podcast: 12 February 2013 AID - 10.1126/scisignal.2004007 DP - 2013 Feb 12 TA - Science Signaling PG - pc5--pc5 VI - 6 IP - 262 4099 - http://stke.sciencemag.org/content/6/262/pc5.short 4100 - http://stke.sciencemag.org/content/6/262/pc5.full SO - Sci. Signal.2013 Feb 12; 6 AB - This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.