PT  - JOURNAL ARTICLE
AU  - Semenza, Gregg L.
AU  - Hubbi, Maimon E.
AU  - VanHook, Annalisa M.
TI  - <em>Science Signaling</em> Podcast: 12 February 2013
AID  - 10.1126/scisignal.2004007
DP  - 2013 Feb 12
TA  - Science Signaling
PG  - pc5--pc5
VI  - 6
IP  - 262
4099  - http://stke.sciencemag.org/content/6/262/pc5.short
4100  - http://stke.sciencemag.org/content/6/262/pc5.full
SO  - Sci. Signal.2013 Feb 12; 6
AB  - This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.