RT Journal Article
SR Electronic
T1 <em>Science Signaling</em> Podcast: 12 February 2013
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP pc5
OP pc5
DO 10.1126/scisignal.2004007
VO 6
IS 262
A1 Semenza, Gregg L.
A1 Hubbi, Maimon E.
A1 VanHook, Annalisa M.
YR 2013
UL http://stke.sciencemag.org/content/6/262/pc5.abstract
AB This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.