RT Journal Article
SR Electronic
T1 GPR15 Gets T<sub>regs</sub> to Guard the Gut
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP ec146
OP ec146
DO 10.1126/scisignal.2004440
VO 6
IS 281
A1 Mueller, Kristen L.
YR 2013
UL http://stke.sciencemag.org/content/6/281/ec146.abstract
AB The large intestine is the site that is typically most inflamed in Crohn’s disease and ulcerative colitis, which are thought to result when the immune system is not able to keep the peace with trillions of resident gut microbes. The immune system does this by recruiting specific cell populations, like regulatory T cells (Tregs), to the gut. Kim et al. now suggest that the orphan G protein–coupled receptor GPR15 is expressed by Tregs and required for Treg homing to the large intestine in mice. S. V. Kim, W. V. Xiang, C. Kwak, Y. Yang, X. W. Lin, M. Ota, U. Sarpel, D. B. Rifkin, R. Xu, D. R. Littman, GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science 340, 1456–1459 (2013). [Abstract] [Full Text]