RT Journal Article SR Electronic T1 The IP3 Receptor as a Hub for Bcl-2 Family Proteins in Cell Death Control and Beyond JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP pe4 OP pe4 DO 10.1126/scisignal.2005093 VO 7 IS 312 A1 Parys, Jan B. YR 2014 UL http://stke.sciencemag.org/content/7/312/pe4.abstract AB Bcl-2 family proteins generally have a proapoptotic or antiapoptotic role. In addition to their known roles at the mitochondria, Bcl-2 family proteins also influence signaling at the endoplasmic reticulum by binding to the inositol 1,4,5-trisphosphate receptor (IP3R), the most ubiquitous intracellular Ca2+ channel. Surprisingly, multiple Bcl-2 family proteins target different sites on the IP3R to elicit various effects on IP3R function, which suggests that the IP3R is an important hub for Bcl-2 family proteins in various physiological settings.