RT Journal Article
SR Electronic
T1 The IP<sub>3</sub> Receptor as a Hub for Bcl-2 Family Proteins in Cell Death Control and Beyond
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP pe4
OP pe4
DO 10.1126/scisignal.2005093
VO 7
IS 312
A1 Parys, Jan B.
YR 2014
UL http://stke.sciencemag.org/content/7/312/pe4.abstract
AB Bcl-2 family proteins generally have a proapoptotic or antiapoptotic role. In addition to their known roles at the mitochondria, Bcl-2 family proteins also influence signaling at the endoplasmic reticulum by binding to the inositol 1,4,5-trisphosphate receptor (IP3R), the most ubiquitous intracellular Ca2+ channel. Surprisingly, multiple Bcl-2 family proteins target different sites on the IP3R to elicit various effects on IP3R function, which suggests that the IP3R is an important hub for Bcl-2 family proteins in various physiological settings.