RT Journal Article
SR Electronic
T1 Opposing Feedbacks on Ras Tune Receptor Tyrosine Kinase Signaling
JF Science Signaling
JO Sci. Signal.
FD American Association for the Advancement of Science
SP pe35
OP pe35
DO 10.1126/scisignal.2004808
VO 6
IS 300
A1 Perry, Michael
A1 Desplan, Claude
YR 2013
UL http://stke.sciencemag.org/content/6/300/pe35.abstract
AB Signaling in development is not always on or off; often, distinct intensity and duration of signaling leads to distinct outcomes. This is true for receptor tyrosine kinase (RTK) signaling in many contexts, where negative feedback often plays a role. Although such negative feedback might reduce or even turn off signaling output over time, continued signaling is often maintained for proper cell fate specification. In this issue, Sieglitz et al. identify a positive regulator of Ras-mediated RTK signaling that they name Rau. Rau is necessary to achieve specific signaling intensity for the differentiation of photoreceptors and of glia that wrap axons in the developing Drosophila eye disc. Both the negative regulator Sprouty and Rau influence signaling through the guanosine triphosphatase Ras; specifically, Rau forms a positive feedback loop important for counteracting the Sprouty negative feedback loop.