PT  - JOURNAL ARTICLE
AU  - Neutze, Richard
AU  - VanHook, Annalisa M.
TI  - <em>Science Signaling</em> Podcast: 10 March 2015
AID  - 10.1126/scisignal.aaa9415
DP  - 2015 Mar 10
TA  - Science Signaling
PG  - pc6--pc6
VI  - 8
IP  - 367
4099  - http://stke.sciencemag.org/content/8/367/pc6.short
4100  - http://stke.sciencemag.org/content/8/367/pc6.full
SO  - Sci. Signal.2015 Mar 10; 8
AB  - This Podcast features an interview with Richard Neutze, senior author of a Research Article that appears in the 10 March 2015 issue of Science Signaling, about a new structural study of the photoreceptor rhodopsin. Rhodopsin is a G protein–coupled receptor that is most abundant in the plasma membranes of rod cells of the retina, where it is important for vision in dim light. Light induces a conformational change in rhodopsin that triggers intracellular signaling through G proteins. Crystal structures of rhodopsin have revealed much of the fine structural details of the protein but do not show the structural changes induced by light. Malmerberg et al. used time-resolved wide angle X-ray scattering to study light-induced conformational changes in the structure of rhodopsin in a native membrane and in real time.