RT Journal Article SR Electronic T1 Science Signaling Podcast: 10 March 2015 JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP pc6 OP pc6 DO 10.1126/scisignal.aaa9415 VO 8 IS 367 A1 Neutze, Richard A1 VanHook, Annalisa M. YR 2015 UL http://stke.sciencemag.org/content/8/367/pc6.abstract AB This Podcast features an interview with Richard Neutze, senior author of a Research Article that appears in the 10 March 2015 issue of Science Signaling, about a new structural study of the photoreceptor rhodopsin. Rhodopsin is a G protein–coupled receptor that is most abundant in the plasma membranes of rod cells of the retina, where it is important for vision in dim light. Light induces a conformational change in rhodopsin that triggers intracellular signaling through G proteins. Crystal structures of rhodopsin have revealed much of the fine structural details of the protein but do not show the structural changes induced by light. Malmerberg et al. used time-resolved wide angle X-ray scattering to study light-induced conformational changes in the structure of rhodopsin in a native membrane and in real time.