PT  - JOURNAL ARTICLE
AU  - Newton, Alexandra C.
AU  - Tanzi, Rudolph E.
AU  - VanHook, Annalisa M.
TI  - <em>Science Signaling</em> Podcast for 10 May 2016: PKCα in Alzheimer’s disease
AID  - 10.1126/scisignal.aaf9436
DP  - 2016 May 10
TA  - Science Signaling
PG  - pc11--pc11
VI  - 9
IP  - 427
4099  - http://stke.sciencemag.org/content/9/427/pc11.short
4100  - http://stke.sciencemag.org/content/9/427/pc11.full
SO  - Sci. Signal.2016 May 10; 9
AB  - This Podcast features an interview with Alexandra Newton and Rudolph Tanzi, authors of a Research Article that appears in the 10 May 2016 issue of Science Signaling, about activating mutations in protein kinase Cα that may promote the type of neural defects that characterize Alzheimer’s disease. Alzheimer’s disease is a progressive neurodegenerative disorder that causes cognitive loss and, eventually, death. Alzheimer’s disease is characterized by the accumulation of amyloid-β (Aβ), synaptic depression, and synaptic degeneration. Alfonso et al. found activating mutations in the gene encoding protein kinase Cα (PKCα) in some families with inherited Alzheimer’s disease. Loss of PKCα function prevented Aβ-induced synaptic depression in brain tissue from mice, suggesting that activated forms of PKCα may contribute to Alzheimer’s disease in some patients.Listen to Podcast