PT  - JOURNAL ARTICLE
AU  - Ferrarelli, Leslie K.
TI  - Papers of note in <em>Science Translational Medicine</em>
AID  - 10.1126/scisignal.aaj1832
DP  - 2016 Sep 13
TA  - Science Signaling
PG  - ec213--ec213
VI  - 9
IP  - 445
4099  - http://stke.sciencemag.org/content/9/445/ec213.short
4100  - http://stke.sciencemag.org/content/9/445/ec213.full
SO  - Sci. Signal.2016 Sep 13; 9
AB  - CANCERStemming the regrowth of leukemiaInhibition of BCL-2, MCL-1, and BCL-XL eradicates CML stem cells in a mouse model and primary blast crisis samples.B. Z. Carter, P. Y. Mak, H. Mu, H. Zhou, D. H. Mak, W. Schober, J. D. Leverson, B. Zhang, R. Bhatia, X. Huang, J. Cortes, H. Kantarjian, M. Konopleva, M. Andreeff, Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells. Sci. Transl. Med. 8, 355ra117 (2016). [Abstract]LYSOSOMAL STORAGE DISEASESHeat shock protein to the rescueIncreasing HSP70 expression in lysosomes using the small-molecule arimoclomol ameliorates pathology in several animal models of sphingolipidoses.T. Kirkegaard, J. Gray, D. A. Priestman, K.-L. Wallom, J. Atkins, O. D. Olsen, A. Klein, S. Drndarski, N. H. T. Petersen, L. Ingemann, D. A. Smith, L. Morris, C. Bornæs, S. H. Jørgensen, I. Williams, A. Hinsby, C. Arenz, D. Begley, M. Jäättelä, F. M. Platt, Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses. Sci. Transl. Med. 8, 355ra118 (2016). [Abstract]